Find Funding Opportunities

Currently open RFAs can be found here

Notre Dame Project Development Team: Diagnostics and Therapeutics

Seed funding, up to $10,000, and advice is available for researchers seeking to develop translational research projects. 

SUBMISSION DEADLINE - OPEN, ROLLING SUBMISSIONS

The primary mission of this PDT is to provide expertise in mainly an advisory capacity in the area of drug discovery and, to a certain extent, associated aspects of diagnostics. However, the PDT will support researchers in all areas of translational research. Expertise in appropriate areas is provided by the PDT’s broad membership. As such, this PDT is structured somewhat differently from some of the others in the I-CTSI.  Using the combined input of the members from the three campuses, this PDT will review proposals from any of the I-CTSI partner institutions. Additional faculty members from any of the institutions will be called in to work with the PDT on an ad hoc, case-by-case basis to fill any voids in expertise as proposals are reviewed. Feedback from the PDT to proposal writers will be provided to suggest means of further strengthening of the proposals with the goal of making them more competitive for external funding or commercialization and making them fit more closely the definition of translational research. The PDT will normally meet in person with proposal writers who will have the opportunity to present their proposed research and to receive feedback from the PDT. While the primary emphasis of this PDT is providing guidance, a relatively small amount of seed funding may be available in those cases in which the PDT foresees that preliminary results would be especially beneficial in seeking external funding.

Recent Notre Dame awardees within this program:

  • Professor Joel Boerckel (AME) and Professor Melissa Kacena (IUSM) “Delivery of Recombinant Human Thrombopoietin for Large Bone Defect Regeneration” 
  • Professor Pinar Zorlutuna (AME) “An Engineered Myocardium for Studying the Role of HIF1 in Cardioprotection” 
  • Professor Olaf Wiest (CHEM) and Professor Robers Stahelin (IUSM-SB) “inhibition of ebola virus (EBOV) and EBOV-like particles by targeting the dimer interface of the EBOV matrix protein, VP40”

More information.


Pilot Funding for Research Use of Core Facilities

Two Page Research Plan; $10,000 for use of CTSI-approved facilities within the CTSI system including some Notre Dame facilities

The Indiana CTSI Pilot Funding program is intended to promote the use of technologies and expertise afforded by the Indiana CTSI Core Facilities available at all partner institutions. Successful proposals will demonstrate outstanding scientific merit that can be linked to generating extramural funding or novel intellectual property (IP). Success of the program will be viewed, in part, by the fostering of new funded grants or providing significant contributions to grant renewals. Therefore, proposals will be judged with equal measure on scientific merit and the likelihood of generating new IP or extramural grant support Funding is for utilization of designated Indiana CTSI core facilities only. Information describing each core is available on the CTSI website. Those cores denoted with a CTSI seal are eligible under this program. See the program guidelines for detailed eligibility criteria.  https://www.indianactsi.org/grantinfo

Recent Notre Dame awardees within this program:

  • Anthanasia Panopoulos, Biological Sciences, Identifying novel cell surface GRP78 binding proteins in induces pluripotent stem cells (iPSCs) and cancer stem-like cell populations
  • Joseph O'Tousa, Biological Sciences, Gene expression profiling during neuron regeneration
  • Reggie Hill, Biological Sciences, use of UND Genomics and Bioinformatics Core Facility
  • Giles Duffield, Biological Sciences, use of UND Genomics and Bioinformatics Core Facility
  • Marya Lieberman, Chemistry & Biochemistry, use of UND Mass Spec. & Proteomics Facility
  • Holly Goodson Chemistry & Biochemistry, use of the Notre Dame Genomics and Bioinformatics Facility
  • Kasturi Haldar Biological Sciences, use of the Purdue Translational Facility
  • Siyuan Zhang Biological Sciences, use of the IUSM-SB Flow Cytometry Core

The deadline to apply is April 24, 2017 at 5:00 p.m.

For more information on this award, please see the Indiana CTSI website.

Over the past five years, the Indiana CTSI Core Pilot Grant Program provided more than $1.6M in research funds to CTSI investigators including 20 grants to Notre Dame faculty. For more information or questions, contact us.


Collaboration in Translational Research Pilot Grant Program (CTR)

Ten Page Research Plan; $75,000 to support a collaboration between faculty researchers that cross institutions within the Indiana CTSI (Notre Dame – Purdue – Indiana Universities).

The Indiana Clinical and Translational Science Institute (CTSI) is seeking applicants for the Collaboration in Translational Research (CTR) Pilot Grant Program. The objective of the Indiana CTSI CTR pilot grant program is to foster and encourage collaboration across the Indiana CTSI partner institutions (IU, Purdue, and Notre Dame) and to initiate or continue translational research projects that have very strong and immediate potential to develop into larger, externally funded research programs, or generate novel intellectual property (IP). Proposed projects should have participation by two (or more) principal investigators representing at least two of the sponsoring affiliates for this program. Sponsoring affiliates include: Indiana University School of Medicine (IUSM), IUPUI (non-IUSM), Indiana University-Bloomington, Purdue University-West Lafayette, and University of Notre Dame.


Recent Notre Dame awardees within this program:

  • Ryan Roeder (aerospace and mechanical engineering) - Matthew Allen (IUSM, anatomy and cell biology) received support for their project, "Development of a Rabbit Model for 'Atypical' Fractures in Cortical Bone During Long-Term Bisphosphonate Therapy."
  • Richard Taylor (chemistry & biochemistry) - David John Wild, (IU-Bloomington, informatics and computing) received support for their project, "Cheminformatic big data mining for automated chemical synthesis."
  • Joel Boerckel (aerospace and mechanical engineering) collaboration with Dr.Mervin Yoder at the Indiana University School of Medicine and Dr. Sherry Voytik-Harbin at Purdue University “Mechanical Regulation of Neovascularization” 

For more information on this award or to apply, please visit the Indiana CTSI website.


Indiana Spinal Cord and Brain Injury Research Fund Grant

The State of Indiana established the Indiana Spinal Cord and Brain Injury Research Fund effective July 1, 2007. The fund is to be utilized to support research related to treatment and cure of spinal cord and brain injuries. The overall objective of this request for proposals (RFP) is to foster and encourage research for the prevention, treatment and cure of spinal cord and brain injuries, including acute management, medical complications, rehabilitative techniques, and neuronal recovery. Because the nature and scope of the research proposed may vary, it is anticipated that the size of each award may also vary. Applications to this program are considered small grants and should have a maximum requested amount of $80,000 per year. All applications should be limited to two-year duration.

Recent Notre Dame Awardees

  • Mayland Chang
  • Joseph O'Tousa
  • Vicki Poplis

For more information please see the Indiana CTSI Website


Design and Biostatistics Program (DBP) Pilot Grant

The Design and Biostatistics Program (DBP) of the Indiana Clinical and Translational Science Institute (CTSI) is comprised of 8 units with associated expertise:  1) Department of Biostatistics, IU School of Medicine and Fairbanks School of Public Health; 2) Division of Hereditary Genomics, Department of Medical & Molecular Genetics, IU School of Medicine; 3) Computational Biology, Center for Computational Biology & Bioinformatics, IU School of Medicine; 4) Department of Epidemiology, Fairbanks School of Public Health; 5) Department of Statistics, Purdue College of Science; 6) Department of  Applied & Computational Math & Statistics, Notre Dame School of Science; 7) Department of Statistics, IU Bloomington College of Arts & Sciences; 8) Department of Epidemiology and Biostatistics, IU Bloomington School of Public Health.  

To achieve its objectives and stimulate development for emerging translational research needs, the DBP will fund innovative pilot projects that support methodological research of faculty members in the eight units that comprise the DBP. The total budget for the entire RFA is $20,000, and it is expected that up to two awards will be funded at approximately $10,000 per award for a twelve month duration.  The objective of this mechanism is to fund research proposals that will synergize methodological strengths and translational biomedical research of the DBP, and in particular, the following types of research proposals:

Research projects that propose to develop novel methodology (such as biostatistical, epidemiological, genetic, and bioinformatics methods).

Research projects that match novel methodology with translational science needs.

Research projects that have high potential to obtain external funding.

 Preference will be given to investigators who have not already received extramural funding.   Applications to this program are expected to be $10,000 per award and are of one (1) year duration.

For more information please see the Indiana CTSI Website


Global Health Research Pilot Projects

The Indiana CTSI with the IU Center for Global Health is soliciting proposals from applicants developing or currently involved in collaborative global health research projects. The purpose of this RFA is to foster and encourage the development of new collaborative interdisciplinary research that seeks to identify innovations to address key global health challenges and improve health outcomes in resource limited settings. This RFA will fund pilot research projects with: (1) a high potential for attracting new extramural research funding; (2) a focus on strengthening collaborative multidisciplinary research collaborations between Indiana CTSI partner institutions (IU, Purdue, and Notre Dame) and key academic research centers abroad; and (3) an emphasis in key, high-yield, research-related initiatives, including basic and translational sciences research, biobanking, cancer, population focused disease control, informatics and decision support systems, and implementation research dissemination. 

Projects funded by this RFA will seek to develop new research to address critical global health challenges in resource limited countries and regions. Research should focus on the development of innovations that will: (1) improve population health outcomes, particularly among women, children, and other vulnerable populations; (2) strengthen sustainable health care delivery systems; (3) address major disease burdens in low to middle income countries. Projects must include at least one academic partner outside of the United States.

  • Marya Lieberman (CHEM) "Pharmaceutical Quality in Malawi"
  • Neil Lobo (BIOS) "Screening of cooking shelters against outdoor malaria vectors in southern Zambia; a semi-field study"

For more information


Predoctoral Training Awards in Translational Research

The Indiana Clinical and Translational Sciences Institute (CTSI) is seeking applicants for special predoctoral training awards in translational research.

Criteria for application include:

  • Candidates must have completed at least one year of a pre-doctoral training program but cannot have completed more than their third year (i.e., applicants must be in the second or third year of their pre- doctoral program when they apply).
  • Co-mentorship by faculty investigators from at least two different disciplines (a non-clinician scientist and preferably but limited to clinician). Co-mentors are not limited to faculty CTSI institutions.
  • Research that is translational in nature and takes advantage of the synergism that comes from working at this basic/clinical interface or clinical/community interface.
  • U.S. citizen or permanent resident status.

Interested candidates must be prescreened for eligibility by submitting a copy of their CV to Colleen Gabauer by December 7, 2015 at ictsi@purdue.edu (Phone: 765-496-1016).

Funding is for two years (with the 2nd year of funding contingent upon satisfactory progress). Benefits include a stipend as well as health insurance and partial coverage of tuition and fees. Trainees will be required to participate in a translational science course, attend a National CTSA meeting, and present their work at several Indiana CTSI pre-doctoral gatherings during the academic year.

Recent Notre Dame awardees within this program:

  • James Clancy            Mentor: Crislyn D'Souza-Schorey
  • Kerry Bauer                Mentor: Amanda Hummon
  • Matthew Pruitt            Mentor: Josh Diehl
  • Tim Riley                    Mentor: Brian Baker
  • Kevin O'Brien             Mentor: James Schmiedeler

For more information on this award, please see the Indiana CTSI website.


CTSI Postdoc Challenge: Grant Funding to use CTSI-Designated Core Facilities

The Indiana Clinical and Translational Sciences Institute (CTSI) is seeking applicants for special postdoctoral training awards in translational research. In biomedical terminology, translational research refers to what is popularly termed as "bench to bedside"; the process by which research in the lab translates into patient treatment. Translation involves applying discoveries made during research (in the lab, through animal studies, etc.) to the development of clinical trials and studies in humans, or carrying out research aimed at enhancing the adoption of best practices. 

CTSI-Designated Core Facilities are cores that undergo a yearly accreditation process through the Indiana CTSI for all partner institutions. The Postdoc Challenge offers postdoctoral research associates at Indiana University, Purdue University, and the University of Notre Dame valuable proposal writing and reviewing experience in areas related to translational research through the use of one or more of the CTSI-Designated Core Facilities at these universities. This is a competitive opportunity for two 1-year awards of $5000 each per institution in the form of an expense account for use of core facility services. Funding is to be used only for services provided by the core facilities. Indiana CTSI-Designated Core Facilities are listed on the HUB (https://www.indianactsi.org/servicecores). If you are interested in participating, you must discuss your proposal with your advisor prior to beginning the application process to ensure your participation will be approved.

For more information please see the Indiana CTSI Website


Postdoctoral Training Awards in Translational Research

The Indiana Clinical and Translational Sciences Institute (CTSI) is seeking applicants for postdoctoral training awards in translational research. 

The Indiana Clinical and Translational Sciences Institute (CTSI) is seeking applicants for special postdoctoral training awards in translational research. In biomedical terminology, translational research refers to what is popularly termed as "bench to bedside"; the process by which research in the lab translates into patient treatment. Translation may involve applying discoveries made during research (in the lab, through animal studies, etc.) to the development of clinical trials and studies in humans, or carrying out research aimed at enhancing the adoption of best practices, or both. To be eligible, candidates must have received a PhD or equivalent degree from an accredited domestic or foreign institution. Please refer to the competition guidelines for full eligibility criteria.

Opportunities available for CTSI Postdoctoral Trainees include:

  • Annual stipend aligned with NIH postdoctoral fellowships
  • Mentoring with a faculty member whose research program includes peer reviewed, extramurally funded clinical or translational research
  • Networking with other pre and post-doctoral trainees, program mentors, and allied researchers from multiple institutions in Indiana to develop a cross-disciplinary community of scientists
  • Attendance at a national meeting that involves similar trainees from 40 other medical schools and research institutions
  • Funding is for one year and is renewable for one additional year pending review and demonstration of satisfactory progress

Recent Notre Dame awardees within this program:

  • Ian Sander                  Mentor: Matt Leevy
  • Holly Weiss-Bilka        Mentor: Matt Ravosa
  • Erin Howe                   Mentor: Siyuan Zhang
  • Gail Weaver                Mentor: Josh Shrout

For more information on this award or to apply, please visit the Indiana CTSI website.


Indiana-CTSI: Community Health Engagement Program (CHEP) Request for Applications (RFA) for Community-Based Research Pilot Projects

The Indiana CTSI CHEP is soliciting proposals for community-based research projects. This RFA will fund pilot projects of community-university partnerships focused on program evaluation, feasibility or preliminary data collection for extramural grant submissions.

These projects are to pursue one or both of the following: (1) to improve an important feature of health or health care or (2) to perform a needed evaluation of a health-related program. Projects that propose achieving their objectives by changing (or demonstrating the potential to change) policy, systems, and/or the environment are encouraged.

Applicants must address how the proposed project will incorporate Core Elements of Community-Based Participatory Research (CBPR). There must be both 1) a university partner and 2) a community partner for the project, and one partner must be designated as the Project Lead and the other partner as the Co-Project Lead. Both partners must currently be working in an Indiana-based institution or organization. The university partner must be a “full-time” (>80% FTE) faculty member employed by a college, university or other academic institution of higher education located within the state of Indiana. The community partner must have ≥80% of his/her work assignment based in the community.

Recent Notre Dame awardees within this program:

For more information see the RFA description at Indiana CTSI Hub.


Young Investigator Awards in Translational Research 

The Indiana Clinical and Translational Sciences Institute (CTSI) is seeking applicants for CTSI Young Investigator Awards in Clinical-Translational Research. These awards are designed to provide promising junior investigator faculty with the opportunity to be mentored in research-intensive multi-disciplinary settings toward the goal of developing careers in clinical-translational research.

Benefits include partial salary support, as well as tuition and fees for required and elective coursework, pilot research monies, and travel funds to attend the national CTSI young investigator meeting.

  • US citizens or permanent residents
  • Full-time junior faculty or research scientists, who would be eligible to apply as principal investigator on an NIH grant or career development award, but who have not to date been a principal investigator on an R01 or equivalent grant.
  • Able to identify co-mentors, who are faculty investigators, from at least two different disciplines (preferably a clinician-scientist and a PhD-scientist).
  • Planning on submitting a grant for external funding (either a career development award or independent research grant) during the first 12 months of the award.

Recent Notre Dame awardees within this program:

  • Laurie Littlepage         Department: (Chemistry & Biochemistry)
  • Pascal Jean-Pierre     Department: (Psychology)
  • Jeni Prosperi              Department: IUSM-SB (adjunct in BIOS)

For more information on this award or to apply, please visit the Indiana CTSI website.


Molecular Therapeutics Program Early Stage Drug Discovery Support

Seed funding, up to $15,000, and advice is available for researchers seeking to develop early stage drug discovery projects. 

The Molecular Therapeutics Program, a part of the Indiana Clinical and Translational Sciences Institute, seeks applications for a competitive program that will provide funds and essential consultation to support the early stage development of therapeutics. This opportunity is provided in concert with the newly established Indiana Drug Discovery Alliance (IDDA), a clearinghouse for drug discovery and development resources at the Indiana-CTSI member institutions of Indiana University, Purdue University and the University of Notre Dame.

INFORMATION FOR APPLICANTS: The Molecular Therapeutics Program will support new collaborations and/or the use of core facilities that enable the translation of fundamental research related to drug discovery. Critical project feedback will be provided from a team of experienced industry and academic experts on the group's internal advisory committee, as well as through ad-hoc, project-specific pharmaceutical expert reviewers.

A detailed budget is not required at this time. Support projects will develop a budget of up to $15,000 in consultation with the IDDA.

ELIGIBILITY: Applicants must be full-time researchers (tenure, tenure-track or research faculty) within the Indiana-CTSI partner institutions.

Recent ND Awards:

Bradley Smith, Emil T. Hofman Professor of Chemistry & Biochemistry and a researcher in the Warren Family Research Center for Drug Discovery and Development, from the Molecular Therapeutics Program of the Indiana CTSI for a project entitled “Novel Drug Candidates for Treating Leishmaniasis.” The work will be carried out in collaboration with Miguel Morales, Assistant Professor of Biological Sciences, and a member of the Eck Institute for Global Heath.

More information


Drug Development Services through the Molecular Therapeutics Program

The Molecular Therapeutics Program, a part of the Indiana Clinical and Translational Sciences Institute, has established a service agreement with Covance, Inc. to support early-stage drug discovery within CTSI partners: Indiana University, Purdue University, and the University of Notre Dame. The Molecular Therapeutic Program (MTP) will support early-stage drug development studies through services provided by Covance Inc. and Quintiles Biosciences, two contract research organizations that provide pharmaceutical development services. Small grants are now available to help support a list of services available: 

Tier 1 Screening assays: 

Solubility assay
CYP SP inhibition assay
Metabolic assay
Ames screen

Tier II screening assays: 
Permeability assay 
CYP IC 50 assays
CYP3A4 TD1 Assays
Plasma Protein binding assay
Hepatocytic clearance assay
hERG (Cardiac toxicity)

Screening package: 
Candidate Screening Package (Membrane Permeability and P gp Assessment, Metabolic Stability, and Rat PK)

Tier III screening assays: (in-vivo models): 
Rat PK
Rat Cassette PK
Mouse PK
Mouse cassette PK
A Single Dose Oral Gavage Pilot Toxicity Study in Rats
Dose Formulation Optimization
A Dose Ranging Study in Beagle Dogs given oral doses of test article to assessing toxicity endpoints
A Toxicity and Toxicokinetic Study in Female Rats (Sprague Dawley) Given Daily Doses of Test Article for 4 Days
A Study to Assess Toxicity and Toxicokinetics in Beagle Dogs Given Test Article for 7 Days

For more information on this award, please see the Indiana CTSI website.


CTSI Funding Opportunity for Early Stage Commercialization in Diagnostics and Therapeutics Development

A common critical gap in commercialization of technologies originating from the academic labs is the funding necessary to develop a robust commercialization relevant data package to reduce the risk of investment in early stage technologies. The Indiana CTSIand Indiana University School of Medicine through the office of the Associate Dean for Entrepreneurship and its Industry Collaboration Portal (ICP), are partnering with the newly created Indiana Center for Biomedical Innovation (ICBI) at IU Health to help fill this critical gap through a new support program, Technology Enhancement Awards (TEA), for early stage technologies. The technology may already reside in a start-up company or a clear plan exists to place it into a start-up. The New Program will partner with the highly successful SPARK program at Stanford University.

Request for Proposals: Proposals are requested from Indiana University School of Medicine researchers and founders of start-up companies for funds to advance early stage technologies to commercialization. The technologies may include highly promising therapeutics (small molecule or biologics), diagnostics or biomedical devices. The funds will be used in support of closing the technical data gaps for commercialization.

Funding: The project will receive funding up to $50,000 for a period of 12 months through a milestone based project management mechanism. In addition, advice and mentorship from experts in drug, diagnostics and business development will be available.   

Eligibility:  Applicants must be researchers, including post docs, within the Indiana University School of Medicine. Post-doc applicants will require letter of support from the primary faculty mentor and the department chair.

Contact Information

Submission Checklist

  1. Review the complete guidelines for the RFA.

  2. Complete biographical sketches in NIH format and the budget form in the application link.

  3. Click on the link below for completing the applications procedure: https://icp.medicine.iu.edu/grants-funding/ctsi.html